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It is important to screen patients for outside use, and to educate them about the risks associated with this. Hormone therapy has been shown to be associated with positive outcomes for patients, but there are important metabolic implications of therapy that must be carefully considered when treating patients. Estimation of prevalence of transgenderism has historically been challenging. Many trans men seek maximum virilization, while others desire suppression of their natal secondary sex characteristics only. This means that the patient is likely to take hormones in a responsible manner; has made progress in addressing other identified problems, leading to improved or stable mental health; and has consolidated gender identity through psychotherapy or by life experience in their desired gender role. The Molecular Biology of Cancer: Our group recommends that patients first be started on an alternative form of testosterone until maximum virilization is achieved and maintenance dosing is then necessary.
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Feminizing hormone therapy - Mayo Clinic

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Progesterone , a progestogen , is the other of the two major sex hormones in women. As subcutaneous fat accumulates, [45] dimpling, or cellulite , becomes more apparent on the thighs and buttocks. All aforementioned physical changes can, and reportedly do, change the experience of sensation compared to prior to HRT.
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